It depends on how the scene is made. The most important part is to keep the necessary collisions so that the persons don't move too much.
When you turn off, say a bed, the collision surface is no more and if persons need it this may bring problems in poses and movement. As passthrough is becoming a more popular use, you may expect scene makers to change collision requirements to invisible shapes and rely less on the furniture of the environment. This is likely going to be a small fraction of scenes always but I think it will grow over time.
If you want to have a go and make some changes in scenes, pick one that looks simple in terms of needed collision surfaces, for example with a bed, go to the bed options > Material > Render > Hide material. Try removing or hiding the remaining environment until you only see the people. If the environment is a CUA and can't be hidden or removed, then use a Cube atom to make the necessary collision the persons need, then in the cube options > Material > Alpha adjust to -1.