For clothes, you can set triggers in the Actions section of PoseMe (I think the best way is to have some clothing preset first and load them through the Actions triggers I mentioned, but if you use Runrudolf's Erection and Foreskin Plug-in with its cum clothing set active, you might loose it, and I haven't found any proper way to reload Runrudolf's cum clothing set but manually). A workaround is to set Actions triggers to disable a certain clothing item simulation and to set its alpha (transparency) to zero. For plug-in settings, I guess you can set some person's plug-ins to enabled or disabled through Actions triggers as well. BTW,
@CheesyFX has been missin for a while now. Anyone knows if he/she is OK?