Basically my setup is vam on main drive (nvme SSD) using the var browser plugin but I created a symbolic link between my allpackages folder in vam directory and a repository on a USB hard drive but this could also work with a sata HDD. Basically this plugin caches your stuff on the main drive and loads all the requirements when you load a scene. You'll have longer load times but this way you can keep the hundreds of gb of vars on a larger, slower drive while having in-game performance on par with a clean install.