Try to close HT and set affinity=1,2,3,4,5,6,7,8
I did previously and I don't know if it really helped any, but I can try again. This time I also have ProcessLasso telling my VAM specifically to set CPU affinity to 0-15/P-cores, and enabled "high performance" profile for good measure, which is the first thing to make a noticable difference. But yeah I'll switch back to disabled HT and that SkinMesh.ini affinity setting.
EDIT: No difference with HT off and 1,2,3,4,5,6,7,8 affinity. I'm honestly gonna' switch back because I feel like my overall computer performance was a touch better.
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